Investigate a string of unusual murders where the victims were all recipients of organs from the same donor.

"JENSEN ACKLES DIRECTS ? Sam (Jared Padalecki) and Dean American Horror Story Season 2 Episode 1 (Jensen Ackles) The killer is captured, but things become even more complicated when the brothers find their killer in a trance mumbling an ancient prayer."
Heartache" Photo Credit: Jack Rowand/The CWWhile the CW promo showed flashes of the case they'll be working amidst the dialogue between Sam and Dean over Sam talking about being done with hunting and the sneak peek shows Dean finding them this case, Walking Dead Season 3 Episode 1 it's the CHCH promo that is out that is all about the hunt itself?and they're going to find themselves in a bit of trouble as they hunt down the killer.
Sons of Anarchy Season 5 Episode 6 The CHCH Supernatural season 8 episode 3 promo for "Heartache" (below) shows a closer look at who (or what) they're hunting. She rips out hearts, and there's a look at what could be part of a ritual, with what looks like blood on her face and around her mouth. Her eyes are glowing, and another shot shows that's not all that will be glowing on her. Dean's going to get pinned down, and it looks like she's going to be after his heart next. Will Sam kill her in time before she can do any damage? The answer is no doubt a yes, but is the shot of Sam shouting Dean part of it or part of something else? What exactly have they stumbled upon with this hunt? Who?or what?is the killer going to be praying to